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Fruzaqla (fruquintinib)
Starting Fruzaqla can bring up a lot of questions, for you and for the people who love you. Here you'll find what to expect, how to feel your best day to day and where to get help, so you can focus on your life and time together.
ℹ️ General information to help you and your loved ones talk with your care team, not medical advice. Read our disclaimer.
Targeted therapy pill (VEGFR inhibitor) · Used for: Colorectal cancer
Types and tests it may fit: KRAS G12C colorectal cancer (RAS-mutant), RAS wild-type colorectal cancer (KRAS/NRAS normal), BRAF V600E colorectal cancer
💊 Taken by mouth · Targeted therapy pill (VEGFR inhibitor)
The quick guide
What it is: Targeted therapy pill (VEGFR inhibitor).
How it's given: Capsules by mouth once a day, 3 weeks on and 1 week off.
How it works: Fruzaqla blocks VEGF receptors, cutting off signals tumors use to grow new blood vessels. It's used for metastatic colorectal cancer after chemo and other targeted drugs.
Side effects you may notice, and what helps at home
| Side effect | What can help |
|---|---|
| High blood pressure | Tell your care team; they can help. |
| Dermatitis (skin rash and skin changes) (Hand-foot skin reaction) | Thick fragrance-free moisturizer, sunscreen, gentle soap. |
| Fatigue (extreme tiredness) | Short walks and planned rest. |
| Diarrhea (loose, watery stools) | Fluids, bland food; ask your team about anti-diarrhea medicine early. |
| Protein in the urine | Tell your care team; they can help. |
| Mucositis (mouth sores) | Soft toothbrush and salt-and-baking-soda rinses. |
Not everyone gets these. Your team may suggest other ways to manage them.
Call your care team now if you have:
- Severe headache, confusion or very high blood pressure readings
- Bleeding, black stools or vomiting blood
- Severe belly pain
Call 911 for trouble breathing, chest pain or signs of stroke.
🗓 What to expect
1️⃣ Before you start
- Ask your team for a written schedule and an after-hours phone number.
- Bring a list of all your medicines and supplements.
2️⃣ Each day on treatment
- Take it exactly as prescribed, at about the same time each day.
- Don't crush or split pills unless your team says it's OK.
- If you miss a dose, follow the label instructions or call your pharmacist.
3️⃣ Between doses
- Watch for the side effects below and use the checklist.
- Keep up with blood tests and visits.
- Call your team for anything in the red box.
✅ Side-effect checklist
Print this and check off what you notice so you can tell your team.
| Side effect | Noticed? | Notes for my team |
|---|---|---|
| High blood pressure | ☐ | |
| Dermatitis (skin rash and skin changes) | ☐ | |
| Fatigue (extreme tiredness) | ☐ | |
| Diarrhea (loose, watery stools) | ☐ | |
| Protein in the urine | ☐ | |
| Mucositis (mouth sores) | ☐ |
Help paying for Fruzaqla (fruquintinib)
Fruzaqla (fruquintinib) is made by Takeda.
Official manufacturer program:
- Takeda Here2Assist: Benefits checks, copay help and patient assistance from Takeda.
Copay cards are usually only for people with commercial (job or marketplace) insurance. If you have Medicare or Medicaid, look at free-drug programs and these independent foundations:
- PAN Foundation: Copays and coinsurance, including for people with Medicare, when a disease fund is open.
- HealthWell Foundation: Grants for copays, deductibles and premiums when a fund is open.
- CancerCare Co-Payment Assistance Foundation: Help with treatment copays for insured people under income limits.
- Good Days: Copay help and some travel costs.
- NeedyMeds: Free database of assistance programs, open to anyone.
📋 Medicare: Pills you take at home are usually covered by Medicare drug coverage (Part D). Part B covers some cancer drugs taken by mouth if the same drug comes in an injectable form. See Medicare and your cancer drugs.
More: Help from drug makers · Our guide to paying for cancer treatment.
❓ Questions you and your loved ones can ask
- What is the goal of this treatment for me?
- How will we know if it's working?
- Which side effects should I call about right away, and what number do I call after hours?
- Which medicines, vitamins or supplements should I avoid?
- Will this affect my ability to work, drive or care for my family?
- What will this cost me, and who can help me with coverage?
Support for you and your family
- Fight Colorectal Cancer: Patient guides, advocacy and community
- Colorectal Cancer Alliance: Helpline (877-422-2030) and patient navigation
- CancerCare: Free counseling, support groups and financial help
- Cancer Support Community: Support groups, a helpline and the MyLifeLine online community
Questions people often ask
How does Fruzaqla work?
Fruzaqla blocks VEGF receptors, cutting off signals tumors use to grow new blood vessels.
How is Fruzaqla given?
Capsules by mouth once a day, 3 weeks on and 1 week off.
How is Fruzaqla (fruquintinib) given?
Capsules by mouth once a day, 3 weeks on and 1 week off.
How does Fruzaqla (fruquintinib) work?
Fruzaqla blocks VEGF receptors, cutting off signals tumors use to grow new blood vessels. It's used for metastatic colorectal cancer after chemo and other targeted drugs.
What side effects are common with Fruzaqla (fruquintinib)?
Side effects people often notice include High blood pressure, Dermatitis (skin rash and skin changes), Fatigue (extreme tiredness), Diarrhea (loose, watery stools), and Protein in the urine. Not everyone gets them, and our table above shares tips that may help at home.
When should I call my care team while on Fruzaqla (fruquintinib)?
Call right away if you notice any of these: severe headache, confusion or very high blood pressure readings; bleeding, black stools or vomiting blood; severe belly pain. If you're ever unsure, it's always OK to call.
What cancers is Fruzaqla (fruquintinib) used for?
On this site, we cover Fruzaqla (fruquintinib) for colorectal cancer. Your care team decides whether it fits your situation.
📄 The official FDA label for Fruzaqla (fruquintinib), including its patient information section, is on DailyMed.
Written by the Cancer Side Effects Guide team from FDA labels and leading cancer centers. Not medical advice. · Last updated: October 15, 2026 · How we write
Sources
Last updated: October 15, 2026. We summarize these sources in our own words.