Home › Drugs › Itovebi (inavolisib)
Itovebi (inavolisib)
Starting Itovebi can bring up a lot of questions, for you and for the people who love you. Here you'll find what to expect, how to feel your best day to day and where to get help, so you can focus on your life and time together.
ℹ️ General information to help you and your loved ones talk with your care team, not medical advice. Read our disclaimer.
Targeted therapy pill (PI3K inhibitor) · Used for: Breast cancer
💊 Taken by mouth · Targeted therapy pill (PI3K inhibitor)
The quick guide
What it is: Targeted therapy pill (PI3K inhibitor).
How it's given: Tablets or capsules by mouth once a day, with Ibrance and fulvestrant.
How it works: Itovebi blocks PI3K-alpha and is used with palbociclib and fulvestrant for PIK3CA-mutant HR+/HER2- advanced breast cancer that came back during or soon after hormone therapy.
Side effects you may notice, and what helps at home
| Side effect | What can help |
|---|---|
| High blood sugar | Tell your care team; they can help. |
| Mucositis (mouth sores) | Soft toothbrush and salt-and-baking-soda rinses. |
| Diarrhea (loose, watery stools) | Fluids, bland food; ask your team about anti-diarrhea medicine early. |
| Neutropenia (low blood counts and infection risk) | Wash hands often; check your temperature if you feel unwell. |
| Dermatitis (skin rash and skin changes) | Thick fragrance-free moisturizer, sunscreen, gentle soap. |
Not everyone gets these. Your team may suggest other ways to manage them.
Call your care team now if you have:
- Extreme thirst or frequent urination
- Severe mouth sores that stop you eating
- Call right away for a fever of 100.4°F (38°C) or higher
Call 911 for trouble breathing, chest pain or signs of stroke.
🗓 What to expect
1️⃣ Before you start
- Ask your team for a written schedule and an after-hours phone number.
- Bring a list of all your medicines and supplements.
2️⃣ Each day on treatment
- Take it exactly as prescribed, at about the same time each day.
- Don't crush or split pills unless your team says it's OK.
- If you miss a dose, follow the label instructions or call your pharmacist.
3️⃣ Between doses
- Watch for the side effects below and use the checklist.
- Keep up with blood tests and visits.
- Call your team for anything in the red box.
✅ Side-effect checklist
Print this and check off what you notice so you can tell your team.
| Side effect | Noticed? | Notes for my team |
|---|---|---|
| High blood sugar | ☐ | |
| Mucositis (mouth sores) | ☐ | |
| Diarrhea (loose, watery stools) | ☐ | |
| Neutropenia (low blood counts and infection risk) | ☐ | |
| Dermatitis (skin rash and skin changes) | ☐ |
Help paying for Itovebi (inavolisib)
Itovebi (inavolisib) is made by Genentech (Roche).
Official manufacturer program:
- Genentech Access Solutions: Insurance help, copay assistance and the Genentech Patient Foundation for free medicine.
Copay cards are usually only for people with commercial (job or marketplace) insurance. If you have Medicare or Medicaid, look at free-drug programs and these independent foundations:
- PAN Foundation: Copays and coinsurance, including for people with Medicare, when a disease fund is open.
- HealthWell Foundation: Grants for copays, deductibles and premiums when a fund is open.
- CancerCare Co-Payment Assistance Foundation: Help with treatment copays for insured people under income limits.
- Good Days: Copay help and some travel costs.
- NeedyMeds: Free database of assistance programs, open to anyone.
📋 Medicare: Pills you take at home are usually covered by Medicare drug coverage (Part D). Part B covers some cancer drugs taken by mouth if the same drug comes in an injectable form. See Medicare and your cancer drugs.
More: Help from drug makers · Our guide to paying for cancer treatment.
❓ Questions you and your loved ones can ask
- What is the goal of this treatment for me?
- How will we know if it's working?
- Which side effects should I call about right away, and what number do I call after hours?
- Which medicines, vitamins or supplements should I avoid?
- Will this affect my ability to work, drive or care for my family?
- What will this cost me, and who can help me with coverage?
Support for you and your family
- Susan G. Komen: Breast care helpline, treatment assistance and education
- Living Beyond Breast Cancer: Helpline, peer support and programs for metastatic breast cancer
- CancerCare: Free counseling, support groups and financial help
- Cancer Support Community: Support groups, a helpline and the MyLifeLine online community
Questions people often ask
How does Itovebi work?
Itovebi blocks PI3K-alpha and is used with palbociclib and fulvestrant for PIK3CA-mutant HR+/HER2- advanced breast cancer that came back during or soon after hormone therapy..
How is Itovebi given?
Tablets or capsules by mouth once a day, with Ibrance and fulvestrant.
📄 The official FDA label for Itovebi (inavolisib), including its patient information section, is on DailyMed.
Written by the Cancer Side Effects Guide team from FDA labels and leading cancer centers. Not medical advice. · Last updated: October 15, 2026 · How we write