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Krazati (adagrasib)
Starting Krazati can bring up a lot of questions, for you and for the people who love you. Here you'll find what to expect, how to feel your best day to day and where to get help, so you can focus on your life and time together.
ℹ️ General information to help you and your loved ones talk with your care team, not medical advice. Read our disclaimer.
Targeted therapy pill (KRAS G12C inhibitor) · Used for: Colorectal cancer, Lung cancer
Types and tests it may fit: KRAS G12C colorectal cancer (RAS-mutant)
💊 Taken by mouth · Targeted therapy pill (KRAS G12C inhibitor)
The quick guide
What it is: Targeted therapy pill (KRAS G12C inhibitor).
How it's given: Tablets by mouth twice a day, with or without food. In colorectal cancer it's taken together with Erbitux (cetuximab) infusions.
How it works: Krazati locks the faulty KRAS G12C protein in its 'off' position so it stops sending growth signals. It only works for tumors with the KRAS G12C change. In colorectal cancer it's paired with cetuximab because blocking KRAS alone lets the cancer reroute through EGFR.
Side effects you may notice, and what helps at home
| Side effect | What can help |
|---|---|
| Nausea and vomiting (CINV) | Small bland meals; take anti-nausea medicine as prescribed. |
| Diarrhea (loose, watery stools) | Fluids, bland food; ask your team about anti-diarrhea medicine early. |
| Fatigue (extreme tiredness) | Short walks and planned rest. |
| Dermatitis (skin rash and skin changes) | Thick fragrance-free moisturizer, sunscreen, gentle soap. |
| Dysgeusia (taste changes and appetite loss) (Decreased appetite) | Small, frequent meals; try tart or seasoned foods. |
Not everyone gets these. Your team may suggest other ways to manage them.
Call your care team now if you have:
- Severe or ongoing diarrhea, vomiting or signs of dehydration
- New or worse cough or shortness of breath (possible lung inflammation)
- Yellow skin or eyes, dark urine or belly pain (possible liver problems)
- Fainting or a racing or irregular heartbeat (heart rhythm changes)
Call 911 for trouble breathing, chest pain or signs of stroke.
🗓 What to expect
1️⃣ Before you start
- Ask your team for a written schedule and an after-hours phone number.
- Bring a list of all your medicines and supplements.
2️⃣ Each day on treatment
- Take it exactly as prescribed, at about the same time each day.
- Don't crush or split pills unless your team says it's OK.
- If you miss a dose, follow the label instructions or call your pharmacist.
3️⃣ Between doses
- Watch for the side effects below and use the checklist.
- Keep up with blood tests and visits.
- Call your team for anything in the red box.
✅ Side-effect checklist
Print this and check off what you notice so you can tell your team.
| Side effect | Noticed? | Notes for my team |
|---|---|---|
| Nausea and vomiting (CINV) | ☐ | |
| Diarrhea (loose, watery stools) | ☐ | |
| Fatigue (extreme tiredness) | ☐ | |
| Dermatitis (skin rash and skin changes) | ☐ | |
| Dysgeusia (taste changes and appetite loss) | ☐ |
Help paying for Krazati (adagrasib)
Krazati (adagrasib) is made by Bristol Myers Squibb (including Mirati).
Official manufacturer program:
- BMS Access Support: Benefits checks, copay help for commercial insurance, and referral to free-drug programs.
Copay cards are usually only for people with commercial (job or marketplace) insurance. If you have Medicare or Medicaid, look at free-drug programs and these independent foundations:
- PAN Foundation: Copays and coinsurance, including for people with Medicare, when a disease fund is open.
- HealthWell Foundation: Grants for copays, deductibles and premiums when a fund is open.
- CancerCare Co-Payment Assistance Foundation: Help with treatment copays for insured people under income limits.
- Good Days: Copay help and some travel costs.
- NeedyMeds: Free database of assistance programs, open to anyone.
📋 Medicare: Pills you take at home are usually covered by Medicare drug coverage (Part D). Part B covers some cancer drugs taken by mouth if the same drug comes in an injectable form. See Medicare and your cancer drugs.
More: Help from drug makers · Our guide to paying for cancer treatment.
❓ Questions you and your loved ones can ask
- What is the goal of this treatment for me?
- How will we know if it's working?
- Which side effects should I call about right away, and what number do I call after hours?
- Which medicines, vitamins or supplements should I avoid?
- Will this affect my ability to work, drive or care for my family?
- What will this cost me, and who can help me with coverage?
Support for you and your family
- Fight Colorectal Cancer: Patient guides, advocacy and community
- Colorectal Cancer Alliance: Helpline (877-422-2030) and patient navigation
- LUNGevity: Patient education, support groups and survivorship programs
- GO2 for Lung Cancer: Helpline, biomarker testing support and navigation
- CancerCare: Free counseling, support groups and financial help
- Cancer Support Community: Support groups, a helpline and the MyLifeLine online community
Questions people often ask
How does Krazati work?
Krazati locks the faulty KRAS G12C protein in its 'off' position so it stops sending growth signals.
How is Krazati given?
Tablets by mouth twice a day, with or without food. In colorectal cancer it's taken together with Erbitux (cetuximab) infusions.
📄 The official FDA label for Krazati (adagrasib), including its patient information section, is on DailyMed.
Written by the Cancer Side Effects Guide team from FDA labels and leading cancer centers. Not medical advice. · Last updated: October 15, 2026 · How we write