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Orgovyx (relugolix)
Starting Orgovyx can bring up a lot of questions, for you and for the people who love you. Here you'll find what to expect, how to feel your best day to day and where to get help, so you can focus on your life and time together.
ℹ️ General information to help you and your loved ones talk with your care team, not medical advice. Read our disclaimer.
Hormone therapy (GnRH antagonist / ADT) · Used for: Prostate cancer
💊 Taken by mouth · Hormone therapy (GnRH antagonist / ADT)
The quick guide
What it is: Hormone therapy (GnRH antagonist / ADT).
How it's given: Tablets or capsules by mouth once a day, after a larger first-day dose.
How it works: Orgovyx is a pill that blocks GnRH to quickly lower testosterone (ADT), without the early flare seen with shots.
Side effects you may notice, and what helps at home
| Side effect | What can help |
|---|---|
| Hot flashes | Tell your care team; they can help. |
| Fatigue (extreme tiredness) | Short walks and planned rest. |
| High blood pressure | Tell your care team; they can help. |
| Falls and fractures | Tell your care team; they can help. |
| Constipation (hard or infrequent stools) | Fluids, fiber if allowed, daily walks. |
| Diarrhea (loose, watery stools) | Fluids, bland food; ask your team about anti-diarrhea medicine early. |
Not everyone gets these. Your team may suggest other ways to manage them.
Call your care team now if you have:
- Chest pain, fainting or irregular heartbeat
Call 911 for trouble breathing, chest pain or signs of stroke.
🗓 What to expect
1️⃣ Before you start
- Ask your team for a written schedule and an after-hours phone number.
- Bring a list of all your medicines and supplements.
2️⃣ Each day on treatment
- Take it exactly as prescribed, at about the same time each day.
- Don't crush or split pills unless your team says it's OK.
- If you miss a dose, follow the label instructions or call your pharmacist.
3️⃣ Between doses
- Watch for the side effects below and use the checklist.
- Keep up with blood tests and visits.
- Call your team for anything in the red box.
✅ Side-effect checklist
Print this and check off what you notice so you can tell your team.
| Side effect | Noticed? | Notes for my team |
|---|---|---|
| Hot flashes | ☐ | |
| Fatigue (extreme tiredness) | ☐ | |
| High blood pressure | ☐ | |
| Falls and fractures | ☐ | |
| Constipation (hard or infrequent stools) | ☐ | |
| Diarrhea (loose, watery stools) | ☐ |
Help paying for Orgovyx (relugolix)
Orgovyx (relugolix) is made by Sanofi.
Official manufacturer program:
- Sanofi Patient Connection: Free medicine for people who qualify and insurance help.
Copay cards are usually only for people with commercial (job or marketplace) insurance. If you have Medicare or Medicaid, look at free-drug programs and these independent foundations:
- PAN Foundation: Copays and coinsurance, including for people with Medicare, when a disease fund is open.
- HealthWell Foundation: Grants for copays, deductibles and premiums when a fund is open.
- CancerCare Co-Payment Assistance Foundation: Help with treatment copays for insured people under income limits.
- Good Days: Copay help and some travel costs.
- NeedyMeds: Free database of assistance programs, open to anyone.
📋 Medicare: Pills you take at home are usually covered by Medicare drug coverage (Part D). Part B covers some cancer drugs taken by mouth if the same drug comes in an injectable form. See Medicare and your cancer drugs.
More: Help from drug makers · Our guide to paying for cancer treatment.
❓ Questions you and your loved ones can ask
- What is the goal of this treatment for me?
- How will we know if it's working?
- Which side effects should I call about right away, and what number do I call after hours?
- Which medicines, vitamins or supplements should I avoid?
- Will this affect my ability to work, drive or care for my family?
- What will this cost me, and who can help me with coverage?
Support for you and your family
- ZERO Prostate Cancer: Patient navigation (ZERO360), financial help and support
- CancerCare: Free counseling, support groups and financial help
- Cancer Support Community: Support groups, a helpline and the MyLifeLine online community
Questions people often ask
How does Orgovyx work?
Orgovyx is a pill that blocks GnRH to quickly lower testosterone (ADT), without the early flare seen with shots..
How is Orgovyx given?
Tablets or capsules by mouth once a day, after a larger first-day dose.
📄 The official FDA label for Orgovyx (relugolix), including its patient information section, is on DailyMed.
Written by the Cancer Side Effects Guide team from FDA labels and leading cancer centers. Not medical advice. · Last updated: October 15, 2026 · How we write