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Rybrevant (amivantamab)
Starting Rybrevant can bring up a lot of questions, for you and for the people who love you. Here you'll find what to expect, how to feel your best day to day and where to get help, so you can focus on your life and time together.
ℹ️ General information to help you and your loved ones talk with your care team, not medical advice. Read our disclaimer.
Targeted antibody (EGFR and MET) · Used for: Lung cancer
💉 Given by IV or injection · Targeted antibody (EGFR and MET)
The quick guide
What it is: Targeted antibody (EGFR and MET).
How it's given: An IV infusion weekly at first, then every 2 or 3 weeks (an under-the-skin form is also available). The first dose is split over 2 days.
How it works: Rybrevant blocks both EGFR and MET and helps immune cells attack the cancer. It's used for EGFR exon 20 insertion lung cancer, and with Lazcluze or chemo for common EGFR mutations.
Side effects you may notice, and what helps at home
| Side effect | What can help |
|---|---|
| Diarrhea (loose, watery stools) | Fluids, bland food; ask your team about anti-diarrhea medicine early. |
| Dermatitis (skin rash and skin changes) (Acne-like rash and dry skin) | Thick fragrance-free moisturizer, sunscreen, gentle soap. |
| Sore skin around nails | Tell your care team; they can help. |
| Mucositis (mouth sores) | Soft toothbrush and salt-and-baking-soda rinses. |
| Dysgeusia (taste changes and appetite loss) (Decreased appetite) | Small, frequent meals; try tart or seasoned foods. |
| Infusion reactions | Tell your care team; they can help. |
| Swelling | Tell your care team; they can help. |
Not everyone gets these. Your team may suggest other ways to manage them.
Call your care team now if you have:
- New or worse cough, shortness of breath or fever (possible lung inflammation)
- Severe or ongoing diarrhea
- Eye pain or vision changes
- Severe skin reaction with blisters or peeling
- Chills, shortness of breath or flushing during the infusion
- Leg swelling or pain (possible blood clots)
Call 911 for trouble breathing, chest pain or signs of stroke.
🗓 What to expect
1️⃣ Before you start
- Ask your team for a written schedule and an after-hours phone number.
- Bring a list of all your medicines and supplements.
2️⃣ During each infusion
- You'll get the medicine through an IV in a clinic; nurses check you during the infusion.
- Tell the nurse right away about chills, itching, flushing or trouble breathing.
- Bring a snack, water and something to pass the time.
3️⃣ Between doses
- Watch for the side effects below and use the checklist.
- Keep up with blood tests and visits.
- Call your team for anything in the red box.
✅ Side-effect checklist
Print this and check off what you notice so you can tell your team.
| Side effect | Noticed? | Notes for my team |
|---|---|---|
| Diarrhea (loose, watery stools) | ☐ | |
| Dermatitis (skin rash and skin changes) | ☐ | |
| Sore skin around nails | ☐ | |
| Mucositis (mouth sores) | ☐ | |
| Dysgeusia (taste changes and appetite loss) | ☐ | |
| Infusion reactions | ☐ | |
| Swelling | ☐ |
Help paying for Rybrevant (amivantamab)
Rybrevant (amivantamab) is made by Johnson & Johnson.
Official manufacturer program:
- J&J withMe: Cost support, insurance help and nurse support for Johnson & Johnson medicines.
Copay cards are usually only for people with commercial (job or marketplace) insurance. If you have Medicare or Medicaid, look at free-drug programs and these independent foundations:
- PAN Foundation: Copays and coinsurance, including for people with Medicare, when a disease fund is open.
- HealthWell Foundation: Grants for copays, deductibles and premiums when a fund is open.
- CancerCare Co-Payment Assistance Foundation: Help with treatment copays for insured people under income limits.
- Good Days: Copay help and some travel costs.
- NeedyMeds: Free database of assistance programs, open to anyone.
📋 Medicare: Medicare Part B usually covers drugs given by infusion in a doctor's office or hospital outpatient clinic. You typically pay 20% after the Part B deductible. See Medicare and your cancer drugs.
More: Help from drug makers · Our guide to paying for cancer treatment.
❓ Questions you and your loved ones can ask
- What is the goal of this treatment for me?
- How will we know if it's working?
- Which side effects should I call about right away, and what number do I call after hours?
- Which medicines, vitamins or supplements should I avoid?
- Will this affect my ability to work, drive or care for my family?
- What will this cost me, and who can help me with coverage?
Support for you and your family
- LUNGevity: Patient education, support groups and survivorship programs
- GO2 for Lung Cancer: Helpline, biomarker testing support and navigation
- CancerCare: Free counseling, support groups and financial help
- Cancer Support Community: Support groups, a helpline and the MyLifeLine online community
Questions people often ask
How does Rybrevant work?
Rybrevant blocks both EGFR and MET and helps immune cells attack the cancer.
How is Rybrevant given?
An IV infusion weekly at first, then every 2 or 3 weeks (an under-the-skin form is also available). The first dose is split over 2 days.
📄 The official FDA label for Rybrevant (amivantamab), including its patient information section, is on DailyMed.
Written by the Cancer Side Effects Guide team from FDA labels and leading cancer centers. Not medical advice. · Last updated: October 15, 2026 · How we write