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Zepzelca (lurbinectedin)
Starting Zepzelca can bring up a lot of questions, for you and for the people who love you. Here you'll find what to expect, how to feel your best day to day and where to get help, so you can focus on your life and time together.
ℹ️ General information to help you and your loved ones talk with your care team, not medical advice. Read our disclaimer.
Chemotherapy · Used for: Lung cancer
💉 Given by IV or injection · Chemotherapy
The quick guide
What it is: Chemotherapy.
How it's given: An IV infusion every 3 weeks.
How it works: Zepzelca is a chemo that blocks cancer cells from making the proteins they need to grow. It's used with Tecentriq (atezolizumab) as maintenance for extensive-stage small cell lung cancer that hasn't grown after first-line chemo plus immunotherapy.
Side effects you may notice, and what helps at home
| Side effect | What can help |
|---|---|
| Neutropenia (low blood counts and infection risk) | Wash hands often; check your temperature if you feel unwell. |
| Fatigue (extreme tiredness) | Short walks and planned rest. |
| Nausea and vomiting (CINV) | Small bland meals; take anti-nausea medicine as prescribed. |
| Dysgeusia (taste changes and appetite loss) (Decreased appetite) | Small, frequent meals; try tart or seasoned foods. |
| Constipation (hard or infrequent stools) | Fluids, fiber if allowed, daily walks. |
Not everyone gets these. Your team may suggest other ways to manage them.
Call your care team now if you have:
- Call right away for a fever of 100.4°F (38°C) or higher
- Yellow skin or eyes
- Pain or redness where the IV went in
Call 911 for trouble breathing, chest pain or signs of stroke.
🗓 What to expect
1️⃣ Before you start
- Ask your team for a written schedule and an after-hours phone number.
- Bring a list of all your medicines and supplements.
2️⃣ During each infusion
- You'll get the medicine through an IV in a clinic; nurses check you during the infusion.
- Tell the nurse right away about chills, itching, flushing or trouble breathing.
- Bring a snack, water and something to pass the time.
3️⃣ Between doses
- Watch for the side effects below and use the checklist.
- Keep up with blood tests and visits.
- Call your team for anything in the red box.
✅ Side-effect checklist
Print this and check off what you notice so you can tell your team.
| Side effect | Noticed? | Notes for my team |
|---|---|---|
| Neutropenia (low blood counts and infection risk) | ☐ | |
| Fatigue (extreme tiredness) | ☐ | |
| Nausea and vomiting (CINV) | ☐ | |
| Dysgeusia (taste changes and appetite loss) | ☐ | |
| Constipation (hard or infrequent stools) | ☐ |
Help paying for Zepzelca (lurbinectedin)
Zepzelca (lurbinectedin) is made by Jazz Pharmaceuticals.
Official manufacturer program:
- JazzCares (Jazz Pharmaceuticals): Copay savings, insurance help and free-medicine help for people who qualify.
Copay cards are usually only for people with commercial (job or marketplace) insurance. If you have Medicare or Medicaid, look at free-drug programs and these independent foundations:
- PAN Foundation: Copays and coinsurance, including for people with Medicare, when a disease fund is open.
- HealthWell Foundation: Grants for copays, deductibles and premiums when a fund is open.
- CancerCare Co-Payment Assistance Foundation: Help with treatment copays for insured people under income limits.
- Good Days: Copay help and some travel costs.
- NeedyMeds: Free database of assistance programs, open to anyone.
📋 Medicare: Medicare Part B usually covers drugs given by infusion in a doctor's office or hospital outpatient clinic. You typically pay 20% after the Part B deductible. See Medicare and your cancer drugs.
More: Help from drug makers · Our guide to paying for cancer treatment.
❓ Questions you and your loved ones can ask
- What is the goal of this treatment for me?
- How will we know if it's working?
- Which side effects should I call about right away, and what number do I call after hours?
- Which medicines, vitamins or supplements should I avoid?
- Will this affect my ability to work, drive or care for my family?
- What will this cost me, and who can help me with coverage?
Support for you and your family
- LUNGevity: Patient education, support groups and survivorship programs
- GO2 for Lung Cancer: Helpline, biomarker testing support and navigation
- CancerCare: Free counseling, support groups and financial help
- Cancer Support Community: Support groups, a helpline and the MyLifeLine online community
Questions people often ask
How does Zepzelca work?
Zepzelca is a chemo that blocks cancer cells from making the proteins they need to grow.
How is Zepzelca given?
An IV infusion every 3 weeks.
📄 The official FDA label for Zepzelca (lurbinectedin), including its patient information section, is on DailyMed.
Written by the Cancer Side Effects Guide team from FDA labels and leading cancer centers. Not medical advice. · Last updated: October 15, 2026 · How we write