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Lupron Depot (leuprolide acetate)
Starting Lupron Depot can bring up a lot of questions, for you and for the people who love you. Here you'll find what to expect, how to feel your best day to day and where to get help, so you can focus on your life and time together.
ℹ️ General information to help you and your loved ones talk with your care team, not medical advice. Read our disclaimer.
Hormone therapy (GnRH agonist / ADT) · Used for: Prostate cancer
💉 Given by IV or injection · Hormone therapy (GnRH agonist / ADT)
The quick guide
What it is: Hormone therapy (GnRH agonist / ADT).
How it's given: A shot every 1, 3, 4 or 6 months.
How it works: Leuprolide tells the brain to stop signaling the testicles to make testosterone (androgen deprivation therapy, ADT).
Side effects you may notice, and what helps at home
| Side effect | What can help |
|---|---|
| Hot flashes | Tell your care team; they can help. |
| Fatigue (extreme tiredness) | Short walks and planned rest. |
| High blood pressure | Tell your care team; they can help. |
| Falls and fractures | Tell your care team; they can help. |
| Lower sex drive | Tell your care team; they can help. |
| Distress (anxiety and worry) (Mood changes) | Talk with someone you trust; ask for counseling. |
Not everyone gets these. Your team may suggest other ways to manage them.
Call your care team now if you have:
- Bone pain, weakness or trouble urinating in the first weeks (tumor flare)
- Chest pain or signs of stroke
Call 911 for trouble breathing, chest pain or signs of stroke.
🗓 What to expect
1️⃣ Before you start
- Ask your team for a written schedule and an after-hours phone number.
- Bring a list of all your medicines and supplements.
2️⃣ During each infusion
- You'll get the medicine through an IV in a clinic; nurses check you during the infusion.
- Tell the nurse right away about chills, itching, flushing or trouble breathing.
- Bring a snack, water and something to pass the time.
3️⃣ Between doses
- Watch for the side effects below and use the checklist.
- Keep up with blood tests and visits.
- Call your team for anything in the red box.
✅ Side-effect checklist
Print this and check off what you notice so you can tell your team.
| Side effect | Noticed? | Notes for my team |
|---|---|---|
| Hot flashes | ☐ | |
| Fatigue (extreme tiredness) | ☐ | |
| High blood pressure | ☐ | |
| Falls and fractures | ☐ | |
| Lower sex drive | ☐ | |
| Distress (anxiety and worry) | ☐ |
Help paying for Lupron Depot (leuprolide acetate)
Lupron Depot (leuprolide acetate) is made by AbbVie.
Official manufacturer program:
- myAbbVie Assist: Free medicine for people who qualify.
Copay cards are usually only for people with commercial (job or marketplace) insurance. If you have Medicare or Medicaid, look at free-drug programs and these independent foundations:
- PAN Foundation: Copays and coinsurance, including for people with Medicare, when a disease fund is open.
- HealthWell Foundation: Grants for copays, deductibles and premiums when a fund is open.
- CancerCare Co-Payment Assistance Foundation: Help with treatment copays for insured people under income limits.
- Good Days: Copay help and some travel costs.
- NeedyMeds: Free database of assistance programs, open to anyone.
📋 Medicare: Medicare Part B usually covers drugs given by infusion in a doctor's office or hospital outpatient clinic. You typically pay 20% after the Part B deductible. See Medicare and your cancer drugs.
More: Help from drug makers · Our guide to paying for cancer treatment.
❓ Questions you and your loved ones can ask
- What is the goal of this treatment for me?
- How will we know if it's working?
- Which side effects should I call about right away, and what number do I call after hours?
- Which medicines, vitamins or supplements should I avoid?
- Will this affect my ability to work, drive or care for my family?
- What will this cost me, and who can help me with coverage?
Support for you and your family
- ZERO Prostate Cancer: Patient navigation (ZERO360), financial help and support
- CancerCare: Free counseling, support groups and financial help
- Cancer Support Community: Support groups, a helpline and the MyLifeLine online community
Questions people often ask
How does Lupron Depot (leuprolide) work?
Leuprolide tells the brain to stop signaling the testicles to make testosterone (androgen deprivation therapy, ADT)..
How is Lupron Depot (leuprolide) given?
A shot every 1, 3, 4 or 6 months.
📄 The official FDA label for Lupron Depot (leuprolide acetate), including its patient information section, is on DailyMed.
Written by the Cancer Side Effects Guide team from FDA labels and leading cancer centers. Not medical advice. · Last updated: October 15, 2026 · How we write