Home › Drugs › Colorectal cancer

Colorectal cancer drugs

Seeing a long list of drug names can feel overwhelming. Here they're grouped the way care teams usually think about them, so you and your family can find where you are.

ℹ️ General information to help you and your loved ones talk with your care team, not medical advice. Read our disclaimer.

Drugs by line of therapy

Which line a drug is used in depends on your cancer's stage, biomarkers, earlier treatment and overall health. Your care team will decide what's right for you. Many drugs are used in more than one line.

🌱 Early-stage (before or after surgery)

1️⃣ First-line for advanced cancer

2️⃣ Second-line

➡️ Later lines

Browse colorectal cancer drug guides

5-FU (fluorouracil)Chemotherapy (antimetabolite)Avastin (bevacizumab)Targeted therapy (VEGF antibody)Braftovi (encorafenib)Targeted therapy pill (BRAF inhibitor)Camptosar (irinotecan)Chemotherapy (topoisomerase inhibitor)Eloxatin (oxaliplatin)Chemotherapy (platinum drug)Enhertu (fam-trastuzumab deruxtecan)Antibody-drug conjugate (HER2-directed)Erbitux (cetuximab)Targeted antibody (EGFR inhibitor)Fruzaqla (fruquintinib)Targeted therapy pill (VEGFR inhibitor)Keytruda (pembrolizumab)Immunotherapy (PD-1 blocker)Krazati (adagrasib)Targeted therapy pill (KRAS G12C inhibitor)Lonsurf (trifluridine and tipiracil)Chemotherapy pillLumakras (sotorasib)Targeted therapy pill (KRAS G12C inhibitor)Opdivo (nivolumab)Immunotherapy (PD-1 blocker)Stivarga (regorafenib)Targeted therapy pill (multikinase inhibitor)Tukysa (tucatinib)Targeted therapy pill (HER2 inhibitor)Vectibix (panitumumab)Targeted antibody (EGFR inhibitor)Vitrakvi (larotrectinib)Targeted therapy pill (TRK inhibitor)Xeloda (capecitabine)Chemotherapy pillYervoy (ipilimumab)Immunotherapy (CTLA-4 blocker)

More treatment options →

Back to the colorectal cancer overview.

Written by the Cancer Side Effects Guide team from FDA labels and leading cancer centers. Not medical advice. · Last updated: October 15, 2026 · How we write

Not medical advice. This page is general information to help you talk with your care team. It can't replace advice from your doctor or nurse. If you have a fever of 100.4°F (38°C) or higher during treatment, or any symptom that worries you, call your care team now. In an emergency, call 911.