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Neuropathy (numbness and tingling)

Some drugs, especially oxaliplatin, paclitaxel, docetaxel and some others, can damage nerves in the hands and feet. This is called peripheral neuropathy.

When it happens

It may start during treatment and can build with each dose. It often improves after treatment, but it can last. Cleveland Clinic notes that for most people feeling returns gradually, but some have symptoms for months or years.

What helps at home

Tell your team about tingling early. They may adjust the dose to protect your nerves.
Protect your feet: wear shoes, check them daily for cuts.
Use non-slip mats and night lights to prevent falls.
Test bath water with your elbow, since you may not feel heat in your hands.
With oxaliplatin, avoid cold drinks and wear gloves in the cold for a few days after each dose.
Ask about physical therapy.

Call your care team now if you have:

Trouble walking, buttoning clothes or holding things
You fall
Numbness that's spreading or getting worse quickly

Call 911 for trouble breathing, chest pain or signs of stroke.

Drugs on this site linked to neuropathy

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💬 What experts are saying

OncLive reported on a large trial in people getting FOLFOX for colon cancer. IV calcium and magnesium given around the infusion did not prevent oxaliplatin nerve problems. Telling your team about tingling early, so they can adjust the dose, is still the main tool.

Source: IV Calcium/Magnesium Has No Effect on Oxaliplatin-Induced Neuropathy (OncLive, July 6, 2013)

Find support

CancerCare: Free counseling, support groups and financial help
Cancer Support Community: Support groups, a helpline and the MyLifeLine online community
Imerman Angels: Free one-on-one matching with a survivor or caregiver mentor
American Cancer Society: 24/7 helpline (1-800-227-2345), rides to treatment, lodging and information

Common questions

How do I manage neuropathy in my feet?

Protective shoes, daily foot checks, fall-proofing your home, and telling your team so they can adjust treatment.

Is neuropathy from chemo permanent?

Often it gets better, but for some people it lasts. Early reporting helps.

Written by the Cancer Side Effects Guide team from FDA labels and leading cancer centers. Not medical advice. · Last updated: October 15, 2026 · How we write

Not medical advice. This page is general information to help you talk with your care team. It can't replace advice from your doctor or nurse. If you have a fever of 100.4°F (38°C) or higher during treatment, or any symptom that worries you, call your care team now. In an emergency, call 911.